ADC Therapeutics SA focuses on advancing its proprietary antibody drug conjugate (ADC) technology platform to transform the treatment paradigm for patients with hematologic malignancies and solid tumors. Its flagship product is ZYNLONTA, a CD19-directed ADC, received accelerated approval from the U.S. Food and Drug Administration and conditional approval from the European Commission for the treatment of relapsed or refractory diffuse large B-cell lymphoma (DLBCL) after two or more lines of systemic therapy. The company is also seeking to continue expanding ZYNLONTA into international markets and into earlier lines of DLBCL and indolent lymphomas, including follicular lymphoma (FL) and marginal zone lymphoma (MZL) as a single agent and in combination through its LOTIS-5 confirmatory Phase 3 clinical trial and LOTIS-7 Phase 1b clinical trial, as well as through investigator-initiated trials (IITs). In addition, it is investigating a CD-22 targeted compound, ADCT-602 that is in a Phase 1/2 investigator-initiated study in relapsed or refractory B-cell acute lymphoblastic leukemia. Further, its clinical-stage pipeline consists of ADCT-601 (mipasetamab uzoptirine) targeting AXL as a single agent and/or in combination in sarcoma, pancreatic, and NSCLC, as well as pre-clinical stage pipeline includes a portfolio of next generation investigational ADCs targeting Claudin-6, NaPi2b, PSMA, and other undisclosed targets. The company was incorporated in 2011 and is headquartered in Epalinges, Switzerland.
Zynlonta's Challenges | ADC Therapeutics faces market headwinds for its flagship product Zynlonta, with sales falling short of expectations amid fierce competition in DLBCL treatment |
Clinical Pipeline | Explore ADC Therapeutics' ongoing trials, including LOTIS-5 and LOTIS-7, which could potentially expand Zynlonta's indications and market reach |
Growth Prospects | Delve into ADC Therapeutics' strategies for label expansion and combination therapies, which may unlock new market opportunities and bolster Zynlonta's position |
Financial Outlook | Analyst price targets range from $6 to $10 per share, with an $8 target from RBC Capital Markets, reflecting cautious optimism amid market challenges |
Metrics to compare | ADCT | Sector Sector - Average of metrics from a broad group of related Healthcare sector companies | Relationship RelationshipADCTPeersSector | |
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P/E Ratio | −0.8x | −4.0x | −0.6x | |
PEG Ratio | 0.17 | −0.03 | 0.00 | |
Price/Book | −1.0x | 2.9x | 2.6x | |
Price / LTM Sales | 2.3x | 36.7x | 3.1x | |
Upside (Analyst Target) | 362.2% | 779.1% | 55.2% | |
Fair Value Upside | Unlock | 27.6% | 9.8% | Unlock |