AdAlta Ltd (ASX:1AD) has been selected for an extended oral presentation at the 11th Molecular Pharmacology of GPCRs meeting to be held in Melbourne from November 15-17, 2023.
An abstract describing the development and clinically effective dose estimation for the company’s lead product AD-214 has been accepted as a poster and selected for oral presentation at MPGPCR 2023 at the Monash Institute of Pharmaceutical Sciences.
One of four selected
The poster, which will be presented by senior scientist Dr Jason Lynch, is one of just four selected for oral presentation at this important meeting.
MPGPCR 2023 will feature presentations from leading international researchers showcasing new molecular insights, the latest tools and technologies that are changing the understanding of the G-protein coupled receptor (GPCR) function, and translation of basic research into the clinic.
GPCRs are a very important class of drug targets that historically have been difficult for antibodies to address with AD-214 using AdAlta’s i-body® technology to target a GPCR known as CXCR4 with antibody-like precision.
AD-214 targets CXCR4
AD-214 is the only product targeting CXCR4 for fibrotic diseases such as Idiopathic Pulmonary Fibrosis (IPF) and is believed to be the most advanced antibody-like product in active development for IPF, highlighting the power of the i-body® platform to do what antibodies cannot.
The poster ‘Clinical dose estimation for anti-CXCR4 i-body-Fc fusion AD-214 for the treatment of fibrotic disease’ will be at 5.00pm AEST on Wednesday, November 15, 2023.
It will focus on studies and dose simulations supporting the efficacy of AD-214’s target intravenous product and the feasibility of an enhanced subcutaneous product.
The presentation titled ‘Anti CXCR4 i-body-Fc fusion AD-214 for the treatment of fibrotic diseases’ will take place at 12.30pm AEST on Thursday, November 16, 2023.
This will focus on the discovery and characterisation of AD-214, the clinical pharmacology observed in Phase I trials and the clinical dosing simulation that these enabled.
Registrations
Registrations for MPGPCR 2023 close on October 25, 2023, and further details can be found here - https://www.monash.edu/mips/news-events/mpgpcr-2023